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KMID : 0984920080100020046
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Journal of Skin Barrier Research
2008 Volume.10 No. 2 p.46 ~ p.49
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Repeated antigen exposure and allergic contact dermatitis
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Lee Ai-Young
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Abstract
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Contact allergens themselves are not enough to predict the development of allergic contact dermatitis(ACD). Recommendation of repeated insult patch tests(RIPTs) as methods of safety prediction for topical products suggests that repeated exposure to sufficient allergens could be appropriate for sensitivity induction and ACD development. A significant association between hand eczema and nickel allergy, and between polysensitization and leg ulcer duration more than 5 years could reflect the role of repeated exposure in ACD development. Repeated exposure to allergens may involve in high incidence of ACD in atopic dermatitis. Identification of risk factors for ACD development is needed for its prevention. Taking into consideration of the above mentioned results, repeated exposure to allergens should avoid prevention and/or control of ACD development.
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KEYWORD
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contact allergens, repeated exposure, allergic contact dermatitis, prevention
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